π-烯丙基三羰基铁内酯配合物在牛海绵肽A合成中的应用：一种有效的DNA聚合酶β和HIV逆转录酶抑制剂。
Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV revers transcriptase.
作者信息
Hollowood Christopher J, Yamanoi Shigeo, Ley Steven V
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
出版信息
Org Biomol Chem. 2003 May 21;1(10):1664-75. doi: 10.1039/b301676p.
DOI:10.1039/b301676p
PMID:12926353
Abstract
The total synthesis of taurospongin A by two new approaches has been achieved where pi-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.
摘要
通过两种新方法实现了牛海绵肽A的全合成，其中π-烯丙基三羰基铁内酯配合物已被用于控制亲核试剂对位于这些配合物侧链中的羰基单元的高度立体选择性加成。
Zotero 插件