Jimenez J J, Huang H S
Department of Medicine, University of Miami School of Medicine, FL 33101.
Cytokine. 1992 Nov;4(6):551-4. doi: 10.1016/1043-4666(92)90018-m.
Recently, interleukin 1 (IL-1) was shown to protect rats from ARA-C-induced alopecia. The present study was designed to investigate the effect of combination rHu-IL-1 and ARA-C on transplantable chloroleukemia (C51) and at the same time evaluate the protective effect of IL-1 on the ARA-C-induced alopecia in the rat model. In vitro, IL-1 had no direct effect on growth, viability or differentiation of C51 cells, neither did IL-1 protect the C51 cells from ARA-C cytotoxicity. In vivo, the combination treatment of ARA-C + IL-1 aborted the development of transplanted chloroleukemia in 100% of rats, vs 60%, 10% and 0% survival for rats treated with IL-1, ARA-C and buffer respectively. All rates treated with ARA-C alone developed complete body alopecia. In contrast, none of the rats treated with combination IL-1 and ARA-C combination developed alopecia. Thus, IL-1 demonstrated a double beneficial effect, synergism with ARA-C against the leukemic cells on the one hand, and protection from ARA-C-induced alopecia, on the other.
最近，白细胞介素1（IL-1）被证明可保护大鼠免受阿糖胞苷（ARA-C）诱导的脱发。本研究旨在调查重组人IL-1（rHu-IL-1）与ARA-C联合使用对可移植性氯白血病（C51）的影响，同时评估IL-1在大鼠模型中对ARA-C诱导的脱发的保护作用。在体外，IL-1对C51细胞的生长、活力或分化没有直接影响，IL-1也不能保护C51细胞免受ARA-C的细胞毒性作用。在体内，ARA-C + IL-1联合治疗使100%的大鼠移植性氯白血病的发展停止，而单独用IL-1、ARA-C和缓冲液治疗的大鼠存活率分别为60%、10%和0%。所有单独用ARA-C治疗的大鼠均出现全身脱发。相比之下，用IL-1和ARA-C联合治疗的大鼠均未出现脱发。因此，IL-1显示出双重有益作用，一方面与ARA-C协同对抗白血病细胞，另一方面防止ARA-C诱导的脱发。
