甲状腺激素受体在颅内脑膜瘤中的表达。
Expression of thyroid hormone receptors in intracranial meningiomas.
作者信息
Wang Chih-Jen, Lin Pi-Chu, Howng Shen-Long
机构信息
Department of Neurosurgery, Kaohsiung Medical University, Kaohsiung, Taiwan.
出版信息
Kaohsiung J Med Sci. 2003 Jul;19(7):334-8. doi: 10.1016/S1607-551X(09)70434-6.
Thyroid hormone has a unique function in human organs. Many of its effects occur at the level of gene expression and are mediated by thyroid hormone receptors (TRs). We investigated the relationship between TRs and the prognosis of meningiomas. We investigated TR expression in human intracranial meningiomas using reverse transcription-polymerase chain reaction. Specimens of 25 tumors were obtained by craniotomy from various intracranial meningiomas. We found that the expression of TRs was receptor subtype- and cell type-dependent. Human TR alpha1 (hTR alpha1) was expressed in nine cases, hTR alpha2 was expressed in 14 cases, and both hTR alpha1 and hTR alpha2 were expressed in five cases; hTR beta1 was expressed in nine cases of recurrent or malignant tumors. The expression of hTR beta1 may be an indicator of recurrent or malignant meningiomas.
甲状腺激素在人体器官中具有独特的功能。其许多作用发生在基因表达水平，并由甲状腺激素受体（TRs）介导。我们研究了TRs与脑膜瘤预后之间的关系。我们使用逆转录聚合酶链反应研究了人颅内脑膜瘤中TR的表达。通过开颅手术从各种颅内脑膜瘤中获取了25个肿瘤标本。我们发现TRs的表达取决于受体亚型和细胞类型。人TRα1（hTRα1）在9例中表达，hTRα2在14例中表达，hTRα1和hTRα2在5例中均有表达；hTRβ1在9例复发或恶性肿瘤中表达。hTRβ1的表达可能是复发或恶性脑膜瘤的一个指标。
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