在过表达β1甲状腺激素受体的低分化人肝癌细胞中，3,3',5-三碘-L-甲状腺原氨酸对细胞增殖的刺激作用。

Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor.

作者信息

Lin K H, Lin Y W, Parkison C, Cheng S Y

机构信息

Graduate Institute of Clinical Medicine, Chang Gung College of Medicine and Technology, Taiwan, R.O.C.

出版信息

Cancer Lett. 1994 Oct 14;85(2):189-94. doi: 10.1016/0304-3835(94)90274-7.

DOI:10.1016/0304-3835(94)90274-7

PMID:7954336

Abstract

To understand the role of thyroid hormone nuclear receptors (TRs) in hepatocarcinogenesis, we characterized the TRs in nine human hepatocarcinoma cell lines. The expression of TR proteins is receptor subtype- and cell type-dependent. TR alpha 1 protein expresses similarly at a low level in each of the nine cell lines. In contrast, TR beta 1 is overexpressed in hepatocarcinoma cells which are poorly differentiated. Furthermore, thyroid hormone was found to stimulate the proliferation of cells in which TR beta 1 is overexpressed. These results suggest that TR beta 1 is most likely involved in the differentiation and proliferation of hepatocarcinoma cells. Our studies have shed new light in the understanding of the role of TRs in liver carcinogenesis.

摘要

为了解甲状腺激素核受体（TRs）在肝癌发生中的作用，我们对9种人肝癌细胞系中的TRs进行了表征。TR蛋白的表达取决于受体亚型和细胞类型。TRα1蛋白在9种细胞系中的每一种中均以低水平相似表达。相比之下，TRβ1在低分化的肝癌细胞中过表达。此外，发现甲状腺激素可刺激TRβ1过表达的细胞增殖。这些结果表明，TRβ1很可能参与肝癌细胞的分化和增殖。我们的研究为理解TRs在肝癌发生中的作用提供了新的线索。