Stroev E A, Riazanova E A
Biull Eksp Biol Med. 1992 Dec;114(12):597-8.
Experiments on albino male rats have demonstrated that a single subcutaneous isoprenaline injection produces cardiac calpaine activation and lysosomal labilization in euthyroidized animals. A 10 micrograms/kg triiodothyronine dose and a 50 micrograms/kg L-thyroxin inhibit calpaines and stabilize myocardial lysosomal membranes in intact rats. The effects following myocardial damage do not occur or become less pronounced in hyperthyroidism. Triiodothyronine proved to be more effective.
对白化雄性大鼠的实验表明，单次皮下注射异丙肾上腺素会使甲状腺功能正常的动物出现心肌钙蛋白酶激活和溶酶体不稳定。在完整大鼠中，10微克/千克的三碘甲状腺原氨酸剂量和50微克/千克的L-甲状腺素可抑制钙蛋白酶并稳定心肌溶酶体膜。在甲状腺功能亢进症中，心肌损伤后的这些效应不会出现或变得不那么明显。事实证明，三碘甲状腺原氨酸更有效。
