[去甲氯氮平对大鼠离体心肌溶酶体膜温度敏感性的影响]
[Effect of nonachlazine on the temperature sensitivity of the lysosomal membranes of the heart muscle in rats in vitro].
作者信息
Sysoliatina N A
出版信息
Farmakol Toksikol. 1985 May-Jun;48(3):41-5.
PMID:4029378
Abstract
It has been shown in vitro that nonachlazine stabilizes rat myocardial lysosomal membranes and activates total acid phosphatase in homogenates of rat myocardium. Preliminary addition of nonachlazine to homogenates in two different final concentrations produces unequal changes in total and free activity of acid phosphatase and cathepsin D during 2.5-hour incubation of homogenates at 37 degrees C.
摘要
体外实验表明，诺阿氯嗪可稳定大鼠心肌溶酶体膜，并激活大鼠心肌匀浆中的总酸性磷酸酶。在37℃下将诺阿氯嗪以两种不同终浓度预先添加到匀浆中，在2.5小时的孵育过程中，酸性磷酸酶和组织蛋白酶D的总活性和游离活性会产生不同程度的变化。
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