Abeyagunawardena A S, Goldblatt D, Andrews N, Trompeter R S
Nephrourology Unit, Institute of Child Health, London, UK.
Lancet. 2003 Aug 9;362(9382):449-50. doi: 10.1016/s0140-6736(03)14072-x.
In November, 1999, all children under age 18 years in the UK were offered immunisation with the newly introduced meningococcal C conjugate vaccine (MCCV). In a cohort of 106 patients with nephrotic syndrome, there were 63 relapses during the 12 months before vaccination, and 96 during the equivalent period postvaccination (p=0.009). The relapse rate of nephrotic syndrome increased significantly after administration of MCCV. Whether to vaccinate such children needs to be carefully considered.
1999年11月，英国所有18岁以下儿童都接种了新推出的C群脑膜炎球菌结合疫苗（MCCV）。在一个106例肾病综合征患者的队列中，接种疫苗前12个月有63次复发，接种后同期有96次复发（p = 0.009）。接种MCCV后肾病综合征的复发率显著增加。是否给这类儿童接种疫苗需要仔细考虑。
