Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles. - Suppr | 超能文献

Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles.

作者信息

Ryu Chung Kyu, Choi Ko Un, Shim Ju Yeon, You Hea Jung, Choi Ik Hwa, Chae Mi Jin

机构信息

College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea.

出版信息

Bioorg Med Chem. 2003 Sep 1;11(18):4003-8. doi: 10.1016/s0968-0896(03)00390-0.

DOI:10.1016/s0968-0896(03)00390-0

Abstract

6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl- or 5-methoxy-moieties of compounds 3-4 did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents.

摘要

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