2,5-二取代-6-芳氨基-4,7-苯并咪唑二酮的合成及其抗真菌活性

Synthesis and antifungal activity of 2,5-disubstituted-6-arylamino-4,7-benzimidazolediones.

作者信息

-Ryu Chung-Kyu, Song Eun Ha, Shim Ju-Yeon, You Hea-Jung, Choi Ko Un, Choi Ik Hwa, Lee Eun Young, Chae Mi Jin

机构信息

College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea.

出版信息

Bioorg Med Chem Lett. 2003 Jan 6;13(1):17-20. doi: 10.1016/s0960-894x(02)00856-9.

DOI:10.1016/s0960-894x(02)00856-9

PMID:12467608

Abstract

2,5-Disubstituted-6-arylamino-4,7-benzimidazolediones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Among them, 6-arylamino-5-chloro-2-(2-pyridyl)-4,7-benzimidazolediones exhibited potent antifungal activity against Candida species and Aspergillus niger.

摘要

合成了2,5 - 二取代 - 6 - 芳氨基 - 4,7 - 苯并咪唑二酮，并测试了其对致病真菌的体外抗真菌活性。其中，6 - 芳氨基 - 5 - 氯 - 2 - (2 - 吡啶基) - 4,7 - 苯并咪唑二酮对念珠菌属和黑曲霉表现出强效抗真菌活性。