Nilsson K Peter R, Rydberg Johan, Baltzer Lars, Inganäs Olle
Biomolecular and Organic Electronics, Department of Physics and Measurement Technology, Biology, and Chemistry, Linköping University, SE-581 83 Linköping, Sweden.
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10170-4. doi: 10.1073/pnas.1834422100. Epub 2003 Aug 19.
The optical transitions of a chiral, three-substituted polythiophene with an amino acid function can be tuned by interactions with synthetic peptides. The addition of a positively charged peptide with a random-coil formation will force the polymer to adopt a nonplanar conformation, and the intensity of the emitted light is increased and blue-shifted. After the addition of a negatively charged peptide with a random-coil conformation, the backbone of the polymer adopts a planar conformation and an aggregation of the polymer chains occurs, seen as a red shift and a decrease of the intensity of the emitted light. By adding the positively charged peptide designed to form a four-helix bundle with the negatively charged peptide, the polymer aggregates are disrupted and the intensity of the emitted light is increased because of separation of the polymer chains. This technique could be used as a platform for making novel sensors and biomolecular switches.
具有氨基酸功能的手性三取代聚噻吩的光学跃迁可通过与合成肽的相互作用进行调节。添加具有无规卷曲结构的带正电荷肽会迫使聚合物采取非平面构象，发射光的强度增加且发生蓝移。添加具有无规卷曲构象的带负电荷肽后，聚合物主链采取平面构象，聚合物链发生聚集，表现为发射光的红移和强度降低。通过添加设计为与带负电荷肽形成四螺旋束的带正电荷肽，聚合物聚集体被破坏，由于聚合物链的分离，发射光的强度增加。该技术可作为制造新型传感器和生物分子开关的平台。
