Nilsson K Peter R, Rydberg Johan, Baltzer Lars, Inganäs Olle
Department of Biomolecular and Organic Electronics, Institutionen för Fysik och Mätteknik, Linköping University, SE-581 83 Linköping, Sweden.
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11197-202. doi: 10.1073/pnas.0401853101. Epub 2004 Jul 27.
The self-assembly of a negatively charged conjugated polythiophene derivative and a positively charged synthetic peptide will create a chiral, well ordered supermolecule. This supermolecule has the three-dimensional ordered structure of a biomolecule and the electronic properties of a conjugated polymer. The molecular complex being formed clearly affects the conformation of the polymer backbone. A main-chain chirality, such as a predominantly one-handed helical structure induced by the acid-base complexation between the conjugated polymer and the synthetic peptide, is seen. The alteration of the polymer backbone influences the optical properties of the polymer, seen as changes in the absorption, emission, and Raman spectra of the polymer. The complexation of the polythiophene and the synthetic peptide also induce a change from random-coil to helical structure of the synthetic peptide. The supermolecule described in this article may be used in a wide range of applications such as biomolecular devices, artificial enzymes, and biosensors.
带负电荷的共轭聚噻吩衍生物与带正电荷的合成肽的自组装将形成一种手性、有序的超分子。这种超分子具有生物分子的三维有序结构和共轭聚合物的电子特性。正在形成的分子复合物明显影响聚合物主链的构象。可以看到一种主链手性，例如由共轭聚合物与合成肽之间的酸碱络合诱导的主要为单手螺旋结构。聚合物主链的改变会影响聚合物的光学性质，表现为聚合物吸收、发射和拉曼光谱的变化。聚噻吩与合成肽的络合还会诱导合成肽从无规卷曲结构转变为螺旋结构。本文所述的超分子可用于广泛的应用，如生物分子器件、人工酶和生物传感器。
