Aridogan Buket Cicioglu, Yildirim Mehmet, Baysal Vahide, Inaloz H Serhat, Baz Kiymet, Kaya Selcuk
Department of Microbiology, Faculty of Medicine, University of Suleyman Demirel, Isparta, Turkey.
J Dermatol. 2003 Aug;30(8):602-7. doi: 10.1111/j.1346-8138.2003.tb00442.x.
Behçet's disease (BD) is an inflammatory disease of unknown etiology. Although its pathogenesis is not fully understood, recent studies have suggested that immunological abnormalities and neutrophil hyperfunction may be involved in its etiology and pathophysiology. The immune system in BD can be characterized as a divergent cytokine production profile of the mixed Th1/Th2 cell type. In this study, we investigated the levels of interleukin (IL)-4, IL-10, IL-12, IL-13 and interferon-g in the sera of patients with BD, in comparison with recurrent aphthous stomatitis and healthy controls, to determine the Th1/Th2 profile of the disease. The levels of IL-4, IL-10 and IL-13 were found to be high in active BD patients, and IL-12 and interferon-gamma levels were lower in active BD patients than in inactive BD, recurrent aphthous stomatitis, and control patients.
白塞病（BD）是一种病因不明的炎症性疾病。尽管其发病机制尚未完全明确，但最近的研究表明，免疫异常和中性粒细胞功能亢进可能参与其病因和病理生理过程。BD患者的免疫系统表现为混合Th1/Th2细胞类型的细胞因子产生谱异常。在本研究中，我们检测了BD患者血清中白细胞介素（IL）-4、IL-10、IL-12、IL-13和干扰素-γ的水平，并与复发性阿弗他口炎患者和健康对照进行比较，以确定该疾病的Th1/Th2谱。结果发现，活动期BD患者的IL-4、IL-10和IL-13水平较高，而活动期BD患者的IL-12和干扰素-γ水平低于非活动期BD患者、复发性阿弗他口炎患者和对照患者。
