Department of Gynaecology and Obstetrics, Zhangpu Hospital, Zhangzhou, China.
Department of Internal Medicine, Zhangpu Hospital, Zhangzhou, China.
Front Immunol. 2023 Sep 29;14:1206959. doi: 10.3389/fimmu.2023.1206959. eCollection 2023.
Behcet's disease (BD) is a chronic multi-systemic disease characterized by relapsing-remitting oral ulcers, genital ulcers, ocular inflammatory involvements, and numerous other systemic features. Ocular involvements are quite common in BD and may cause severe tissue damage and potentially blindness. Even though the pathogenesis of BD remains ambiguous, growing evidences have shown that genetic factors, environmental triggers and immunological abnormalities play significant roles in its development and progression. Novel biotherapies targeting IFN-γ, TNF-α and interleukins have been used in recent years. In this review, we mainly pay attention to the ocular involvement of BD, and discuss the current understanding of mechanisms and advances in therapeutic approaches, especially novel biologics. Finally, we discuss the management in patients with pregnancy.
白塞病（BD）是一种慢性多系统疾病，其特征为反复发作的口腔溃疡、生殖器溃疡、眼部炎症性病变以及许多其他全身表现。眼部病变在 BD 中很常见，可导致严重的组织损伤和潜在的失明。尽管 BD 的发病机制仍不清楚，但越来越多的证据表明，遗传因素、环境触发因素和免疫异常在其发展和进展中起重要作用。近年来，针对 IFN-γ、TNF-α 和白细胞介素的新型生物疗法已被应用。在这篇综述中，我们主要关注 BD 的眼部受累，并讨论目前对发病机制和治疗方法进展的认识，特别是新型生物制剂。最后，我们讨论了妊娠患者的管理。
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