Tosti-Guerra C, Carloni V, Morace G, Vitolo A, Morace G
Istituto di Clinica Medica II, Università degli Studi, Firenze.
Cardiologia. 1992 Sep;37(9):615-9.
Ventricular myosin heavy chains serum levels are a new marker of myocardial necrosis. We have studied plasma levels of myosin in 30 patients with unstable angina, 30 patients with acute myocardial infarction and 25 healthy subjects. The myosin peak level was 317 +/- 101 microU/L in angina patients, 2510 +/- 433 microU/L in infarcted patients and 62.3 +/- 17 microU/L in the controls. In both groups, the increase in serum myosin was more marked in those with larger infarction and in those with more severe angina. These data suggest that the measurement of serum myosin can identify the presence of micronecrosis in patients with unstable angina, according to what has been found using other markers of myocellular necrosis.
心室肌球蛋白重链血清水平是心肌坏死的一种新标志物。我们研究了30例不稳定型心绞痛患者、30例急性心肌梗死患者和25名健康受试者的血浆肌球蛋白水平。心绞痛患者的肌球蛋白峰值水平为317±101微单位/升，梗死患者为2510±433微单位/升，对照组为62.3±17微单位/升。在两组中，梗死面积较大和心绞痛较严重的患者血清肌球蛋白升高更为明显。这些数据表明，根据使用其他心肌细胞坏死标志物所发现的情况，测定血清肌球蛋白可识别不稳定型心绞痛患者中微坏死的存在。
