冰岛开角型青光眼的患病率：雷克雅未克眼病研究。

Prevalence of open-angle glaucoma in Iceland: Reykjavik Eye Study.

作者信息

Jonasson F, Damji K F, Arnarsson A, Sverrisson T, Wang L, Sasaki H, Sasaki K

机构信息

Department of Ophthalmology University Hospital of Iceland Landspítalinn, Iceland.

出版信息

Eye (Lond). 2003 Aug;17(6):747-53. doi: 10.1038/sj.eye.6700374.

DOI:10.1038/sj.eye.6700374

PMID:12928689

Abstract

PURPOSE

To establish the age- and sex-specific prevalence of open-angle glaucoma (OAG) subsuming pseudoexfoliation (PEX) in the city of Reykjavik.

METHODS

Participants 50 years of age and older who were part of the Reykjavik Eye Study and classified as having glaucoma were divided into three categories:Category 1: two or more of the following based on optic nerve stereophotograph reading: vertical cup to disc ratio (VCDR) 97.5th percentile (>0.7), focal glaucomatous disc change, C/D asymmetry of 97.5th percentile difference between eyes (>0.2) as well as glaucomatous visual field defect (GVFD). Category 2: 99.5th percentile of VCDR (>0.8) and 99.5% percentile difference between eyes (>/=0.3), without a GVFD. Category 3: VA<3/60 and IOP>99.5th percentile or VA <3/60 and evidence of filtering surgery. For a glaucoma suspect, one of the following was present: VCDR>99.5th percentile (>0.8), focal glaucomatous disc change, C/D asymmetry of 99.5th percentile (> or =0.3), GVFD only, IOP> or =23 mmHg (97.5 percentile). PEX was diagnosed by the presence of a central shield and/or a peripheral band on the anterior lens capsule.

RESULTS

Of 42 persons (22 males and 20 females) with OAG, 13 (31.0%) had PEX. The minimum prevalence of OAG was 4.0% (42/1045) (95% CI 2.8-5.2) for those 50 years and older and 10.3% (95% CI 8.5-12.2) for PEX. The prevalence of OAG increases with age (OR=1.10/year, 95% CI 1.07-1.13, P=0.000) and the same applies for the prevalence of PEX, OR=1.10 (95% CI 1.07-1.12, P=0.000).

CONCLUSION

There is a 10% annual increase for both OAG and PEX in persons 50 years and older.

摘要

目的

确定雷克雅未克市开角型青光眼（OAG，包括假性剥脱性青光眼[PEX]）按年龄和性别的患病率。

方法

雷克雅未克眼病研究中50岁及以上且被归类为患有青光眼的参与者被分为三类：第1类：根据视神经立体照片读数满足以下两项或更多项：垂直杯盘比（VCDR）处于第97.5百分位数（>0.7）、局限性青光眼性视盘改变、双眼之间C/D不对称性处于第97.5百分位数差异（>0.2）以及青光眼性视野缺损（GVFD）。第2类：VCDR处于第99.5百分位数（>0.8）且双眼之间差异处于第99.5百分位数（≥0.3），无GVFD。第3类：视力<3/60且眼压处于第99.5百分位数或视力<3/60且有滤过手术证据。对于青光眼疑似患者，存在以下情况之一：VCDR>第99.5百分位数（>0.8）、局限性青光眼性视盘改变、C/D不对称性处于第99.5百分位数（≥0.3）、仅存在GVFD、眼压≥23 mmHg（第97.5百分位数）。PEX通过在前囊膜上存在中央盾牌和/或周边带进行诊断。

结果

在42例（22例男性和20例女性）OAG患者中，13例（31.0%）患有PEX。50岁及以上人群中OAG的最低患病率为4.0%（42/1045）（95%可信区间2.8 - 5.2），PEX为10.3%（95%可信区间8.5 - 12.2）。OAG的患病率随年龄增加（比值比=1.10/年，95%可信区间1.07 - 1.13，P = 0.000），PEX的患病率也是如此，比值比=1.10（95%可信区间1.07 - 1.12，P = 0.000）。