Cavallini G, De Tata V, Fierabracci V, Giulianotti C, Mosca F, Gori Z
Istituto di Patologia Generale, Università degli Studi, Pisa.
Cardiologia. 1992 Sep;37(9):659-61.
The transmural distribution of the adenosine metabolizing enzyme activities 5'nucleotidase (5'N) and adenosine deaminase (ADA) across the left ventricular wall was explored in rats with heart hypertrophy induced by aortocaval shunt (FAC), or coarctation of the abdominal aorta (S) or by tireotoxicosis (T). FAC caused largest heart hypertrophy with a very short latency (1 day: + 0%, 3.5 days: + 30%, 7 days: + 41%, 21 days: + 49%). A 30% increase in the left ventricle free wall was observed after 3.5, 14 or 28 days of treatment with FAC, T or S respectively. Different changes in enzyme levels and alteration of transmural distribution profiles were observed with the different types of heart hypertrophy. Level of 5'N was decreased with FAC, did not change with T and increased with S; levels of ADA were always increased. The pattern of the transmural distribution of 5'N was affected by S but not by T and FAC, whereas distribution of ADA was not affected by S and T and was altered by FAC transiently.
在由主动脉腔静脉分流术（FAC）、腹主动脉缩窄（S）或甲状腺毒症（T）诱导的心脏肥大的大鼠中，研究了腺苷代谢酶活性5'-核苷酸酶（5'N）和腺苷脱氨酶（ADA）在左心室壁的跨壁分布。FAC导致最大程度的心脏肥大，潜伏期很短（1天：增加0%，3.5天：增加30%，7天：增加41%，21天：增加49%）。分别用FAC、T或S处理3.5、14或28天后，观察到左心室游离壁增加30%。不同类型的心脏肥大观察到酶水平的不同变化和跨壁分布曲线的改变。5'N水平在FAC时降低，在T时不变，在S时升高；ADA水平总是升高。5'N的跨壁分布模式受S影响，但不受T和FAC影响，而ADA的分布不受S和T影响，仅受FAC短暂改变。
