Czarnowski D, Wójcik B, Langfort J, Górski J
Department of Physiology, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1996;41(2):334-40.
Activity of 5'-nucleotidase (5NT) and adenosine deaminase (ADA) in the left heart ventricle was examined at normal heart rate and after atrial pacing in six weeks after constriction of the aorta above or below the renal vessels and in sham operated rats. The aorta constriction above the vessels reduced activity of 5NT by 29% and increased activity of ADA by 33%, whereas the constriction below the vessels resulted in elevated activity of both enzymes: 5NT by 16% and ADA by 145% at normal heart rate. The atrial pacing reduced 5NT activity and did not affect ADA activity in control rats and in those with constriction of the aorta below the vessels. The activity of both enzymes increased after constriction of the aorta above the renal vessels. It is concluded that adenosine metabolism in the hypertrophied heart may be changed due to changes in its production and degradation. Renin-angiotensin-aldosterone system seems to be involved in regulation of the activities of adenosine metabolizing enzymes in the hypertrophied heart.
在肾血管上方或下方缩窄主动脉六周后以及假手术大鼠中，于正常心率和心房起搏后，检测了左心室中5'-核苷酸酶（5NT）和腺苷脱氨酶（ADA）的活性。肾血管上方的主动脉缩窄使5NT活性降低29%，使ADA活性增加33%，而肾血管下方的缩窄导致两种酶的活性均升高：在正常心率下，5NT升高16%，ADA升高145%。心房起搏降低了对照大鼠以及肾血管下方主动脉缩窄大鼠的5NT活性，且未影响ADA活性。肾血管上方的主动脉缩窄后，两种酶的活性均增加。得出的结论是，肥大心脏中的腺苷代谢可能因其产生和降解的变化而改变。肾素-血管紧张素-醛固酮系统似乎参与了肥大心脏中腺苷代谢酶活性的调节。
