Müller Christian, Kuster Gabriela, Büttner Heinz J, Buser Peter
Departemente Innere Medizin, Medizinische Universitätsklinik, Basel, Switzerland.
Herz. 2003 Aug;28(5):374-9. doi: 10.1007/s00059-003-2415-x.
Abstract B-natriuretic peptide (BNP) is a 32-amino acid polypeptide secreted from the cardiac ventricles in response to ventricular volume expansion and pressure overload. BNP levels are elevated in patients with symptomatic left ventricular dysfunction, and levels correlate with severity of symptoms and with prognosis. Numerous studies indicate that BNP may considerably improve the management of patients with heart failure and may become a routine serum parameter in clinical medicine. In this review, the utility of BNP in different clinical settings will be discussed.
摘要 B型利钠肽（BNP）是一种由心室分泌的32个氨基酸的多肽，其分泌是对心室容量扩张和压力过载的反应。有症状的左心室功能不全患者的BNP水平会升高，且该水平与症状严重程度及预后相关。大量研究表明，BNP可能会显著改善心力衰竭患者的管理，并可能成为临床医学中的一项常规血清参数。在本综述中，将讨论BNP在不同临床环境中的应用。
