Frost Harold M
Department of Orthopaedic Surgery, Southern Colorado Clinic, P.O. Box 9000, Pueblo, CO 81008-9000, USA.
J Bone Miner Metab. 2003;21(5):255-60. doi: 10.1007/s00774-003-0418-6.
"Connecting the dots" between diverse clinical and other matters and an updated bone physiology reveals relationships that could modify some ideas about the roles and uses of absorptiometry in "osteoporosis" work. Herein, absorptiometry means that part of "clinical densitometry" that depends on X-ray absorption by bone and other tissues, thus excluding ultrasound methods and magnetic resonance imaging. The modifications concern, in part, some limitations of bone mineral "density" data, the kinds of physiological information that absorptiometry can and cannot provide, the relative importance of bone "mass" and whole-bone strength, how to define and study bone health and "osteoporosis," and two kinds of "osteoporotic fractures." As those modifications concern important national health care issues, they deserve answers based on hard evidence. Identifying those modifications might help others to evaluate them.
将各种临床及其他事项与更新后的骨生理学“串联起来”，揭示了一些关系，这些关系可能会改变关于骨密度测定法在“骨质疏松症”研究中的作用和用途的一些观点。在此，骨密度测定法指的是“临床骨密度测量”中依赖于骨和其他组织对X射线吸收的那部分内容，因此不包括超声方法和磁共振成像。这些改变部分涉及骨矿物质“密度”数据的一些局限性、骨密度测定法能够及无法提供的生理信息类型、骨“质量”与全骨强度的相对重要性、如何定义和研究骨骼健康及“骨质疏松症”，以及两种“骨质疏松性骨折”。由于这些改变涉及重要的国家医疗保健问题，它们需要基于确凿证据给出答案。明确这些改变可能有助于其他人对其进行评估。
