Gbaanador G B, Stothert J C, Basadre J O, Traber L, Linares H A, Traber D L
Department of Surgery, University of Texas Medical School, Houston 77026.
Circ Shock. 1992 Dec;38(4):245-52.
The hemodynamic and lung lymph changes following near-drowning (ND) were studied in sheep. Experimental ND was by transtracheal aspiration of 10 ml/kg body weight of either seawater (SW) or freshwater (FW). Extravascular lung water and lung lymph protein flux were significantly increased, but cardiac index was depressed in both groups following ND. Systemic and pulmonary vascular resistances were markedly elevated with FW compared to only a slight rise with SW. Lung lymph oncotic pressure decreased with SW ND from baseline of 9.7 +/- 0.4 to 6.8 +/- 0.63 mm Hg (P < 0.05). In contrast, FW ND increased lung lymph oncotic pressure from 12.8 +/- 0.9 to 16.6 +/- 1.3 mm Hg (P < 0.05). These data suggest that the changes in lung lymph and hemodynamic response to SW and FW ND differ in sheep. The changes are immediate and profound with SW, but slower in onset and less severe with FW. FW ND is associated with hemolysis, which is absent in SW ND.
对绵羊进行了近溺水（ND）后血流动力学和肺淋巴变化的研究。实验性近溺水是通过经气管吸入10毫升/千克体重的海水（SW）或淡水（FW）。两组近溺水后血管外肺水和肺淋巴蛋白通量均显著增加，但心脏指数降低。与海水组仅略有升高相比，淡水组的全身和肺血管阻力显著升高。海水组近溺水后肺淋巴胶体渗透压从基线的9.7±0.4毫米汞柱降至6.8±0.63毫米汞柱（P<0.05）。相反，淡水组近溺水使肺淋巴胶体渗透压从12.8±0.9毫米汞柱升高至16.6±1.3毫米汞柱（P<0.05）。这些数据表明，绵羊对海水和淡水近溺水的肺淋巴变化及血流动力学反应不同。海水组变化迅速且显著，而淡水组发病较慢且程度较轻。淡水组近溺水与溶血有关，而海水组近溺水则无溶血现象。
