Gao S
Department of Stomatology, First Affiliated Hospital, Hunan Medical University, Changsha.
Zhonghua Kou Qiang Yi Xue Za Zhi. 1992 May;27(3):145-7, 189.
The morphometry of the cells and the nuclei in the spinous cells of oral epithelium in 48 specimens were studied by interactive image analysis system (IBAS-II). Five groups, normal mucosa, oral submucous fibrosis (OSF), leukoplakia, epithelial dysplasia and squamous cell carcinoma, were included. The result showed a progressive reduction in the dimensions (area, perimeter, all kinds of diameter) of the cells from normal mucosa, through OSF, leukoplakia, dysplasia to carcinoma (P < 0.01), while the dimensions of the nuclei did not show significant differences among the groups (P > 0.05), except the minimum diameter, but the nuclear cytoplasmic ratio showed a progressive increase (P < 0.01). The shape factors (form factor [PE] and contour index [CI]) seemed to be less helpful in identification. It indicated that the decrease of cell area of the spinous cell could reflect a malignant progress, and nuclear cytoplasmic ratio might be an objective feature to distinguish carcinoma from other lesions. The result also suggested that the pathological grade of OSF is between normal mucosa and mild epithelial dysplasia.
应用交互式图像分析系统（IBAS-II）对48例标本口腔上皮棘细胞的细胞及细胞核形态进行了研究。研究对象包括五组，即正常黏膜、口腔黏膜下纤维化（OSF）、白斑、上皮发育异常及鳞状细胞癌。结果显示，从正常黏膜经OSF、白斑、发育异常至癌，细胞尺寸（面积、周长、各类直径）逐渐减小（P<0.01），而细胞核尺寸在各组间除最小直径外差异无统计学意义（P>0.05），但核质比呈逐渐增加趋势（P<0.01）。形状因子（形态因子[PE]和轮廓指数[CI]）在鉴别诊断中似乎帮助不大。这表明棘细胞面积减小可反映恶性进展，核质比可能是区分癌与其他病变的客观特征。结果还提示，OSF的病理分级介于正常黏膜与轻度上皮发育异常之间。
