Gao S, Liu S, Shen Z, Peng L
Stomatological Hospital, Tianjin Medical University.
Chin Med J (Engl). 1995 May;108(5):351-4.
The morphometric analysis of the spinous cell in 16 specimens of oral submucous fibrosis (OSF) was made by using interactive image analysis system (IBAS-II). 19 parameters of the size and shape were chosen, and compared with normal mucosa, leukoplakia, dysplasia and carcinoma. The results indicated that the cell dimensions (area, perimeter, all kinds of diameter) and nuclear cytoplasmic ratio in OSF were between normal mucosa and dysplasia as well as carcinoma. The former showed a progressive decrease (P < 0.01), and the latter showed a progressive increase (P < 0.01). The dimensions of the nuclei did not show considerable differences among the groups (P < 0.05). A series of discriminant functions had been developed with stepwise discriminant analysis, the agreement ratio for OSF was 93.75%. The decrease of cell area and the increase of nuclear cytoplasmic ratio could reflect a malignant progress. The cell morphometric model could discriminate OSF well from other groups, suggesting that the change of the epithelium in OSF appearing in the spinous cell is specific itself.
采用交互式图像分析系统（IBAS-II）对16例口腔黏膜下纤维化（OSF）标本中的棘细胞进行形态计量分析。选取了19个大小和形状参数，并与正常黏膜、白斑、发育异常及癌组织进行比较。结果表明，OSF中的细胞尺寸（面积、周长、各种直径）及核质比介于正常黏膜与发育异常及癌组织之间。前者呈逐渐下降趋势（P<0.01），后者呈逐渐上升趋势（P<0.01）。各组间细胞核尺寸差异不显著（P<0.05）。通过逐步判别分析建立了一系列判别函数，OSF的符合率为93.75%。细胞面积减小和核质比增加可反映恶性进展。细胞形态计量模型能很好地将OSF与其他组区分开来，提示OSF中上皮细胞在棘细胞中的变化本身具有特异性。
