Zhou S, Guo F, Li L, Zhou Y, Lei Y, Hu Y, Su H, Chen X, Yin P, Jian X
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China.
Int J Oral Maxillofac Surg. 2008 Dec;37(12):1094-8. doi: 10.1016/j.ijom.2008.06.010. Epub 2008 Aug 5.
Oral submucous fibrosis (OSF), a chronic progressive disorder, is regarded as the premalignant lesion of oral squamous cell carcinoma (OSCC). Its distribution is associated with chewing betel quid (BQ). The objective of the present study was to investigate risk factors for the carcinogenesis of OSF in mainland China. A case-control study was performed in 42 patients with OSCC that originated from OSF and 40 OSF controls. Epidemiological data and information related to risk factors were collected using a short structured questionnaire. Odd ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression analysis. In multivariate analysis, only age, duration of BQ chewing, duration of cigarette smoking, and OSF accompanied by oral leukoplakia or oral lichen planus were associated with significantly increased risk for the malignant transformation of OSF. These findings contribute to current knowledge on the prevention of carcinogenesis of OSF in mainland China.
口腔黏膜下纤维化（OSF）是一种慢性进行性疾病，被视为口腔鳞状细胞癌（OSCC）的癌前病变。其分布与咀嚼槟榔（BQ）有关。本研究的目的是调查中国大陆地区OSF癌变的危险因素。对42例由OSF发展而来的OSCC患者和40例OSF对照者进行了病例对照研究。使用简短的结构化问卷收集了与危险因素相关的流行病学数据和信息。通过逻辑回归分析得出比值比（OR）和95%置信区间（CI）。在多变量分析中，只有年龄、咀嚼槟榔的持续时间、吸烟的持续时间以及伴有口腔白斑或口腔扁平苔藓的OSF与OSF恶变风险显著增加相关。这些发现有助于增进对中国大陆地区OSF癌变预防的现有认识。
