Kald B, Gustafson C, Franzén L, Weström B, Sjödahl R, Tagesson C
Department of Occupational Medicine, University of Linköping, Sweden.
Eur Surg Res. 1992;24(6):325-32. doi: 10.1159/000129224.
We report the presence of platelet-activating factor (PAF-acether; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acether. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this might contribute to the pathophysiology of inflammatory bowel disease.
我们报告了新生大鼠小肠和结肠黏膜中血小板活化因子（PAF-乙醚；1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的存在。PAF-乙醚含量在结肠中高于小肠，在30日龄动物的小肠中低于14日龄动物的小肠。我们还报告，培养的肠上皮细胞（INT 407）在受到钙离子载体A23187刺激时会产生PAF-乙醚，并且INT 407细胞匀浆能够降解PAF-乙醚并形成溶血PAF-乙醚。这些发现表明，肠上皮细胞能够产生和代谢PAF-乙醚，一种强效的炎症介质。作者提出，这可能有助于炎症性肠病的病理生理学。
