离子载体刺激的大鼠嗜碱性白血病细胞产生血小板活化因子-乙酰醚。
Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether.
作者信息
Purdon A D, Yang D C, Smith S, Smith J B
出版信息
Int Arch Allergy Appl Immunol. 1987;82(2):215-7. doi: 10.1159/000234190.
PMID:3100454
Abstract
Ionophore (A23187) stimulated rat basophilic leukemia (RBL-1) cells produce a lipid mediator which caused rabbit platelets to aggregate and which by using platelet-activating factor (PAF)-acether antagonists and high-pressure liquid chromotography was shown to be PAF-acether. Thus RBL-1 cells represent a cell type suitable for studying the coordinated release of three mediators of anaphylaxis: histamine, leukotrienes C4/D4 (slow-reacting substances) and PAF-acether.
摘要
离子载体（A23187）刺激大鼠嗜碱性白血病（RBL-1）细胞产生一种脂质介质，该介质可使兔血小板聚集，并且通过使用血小板活化因子（PAF）-乙醚拮抗剂和高压液相色谱法表明其为PAF-乙醚。因此，RBL-1细胞是一种适合用于研究过敏反应的三种介质（组胺、白三烯C4/D4（慢反应物质）和PAF-乙醚）协同释放的细胞类型。
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