正常及异常个体睾丸发育的遗传决定因素。
Genetic determinants of testis development in normal and abnormal individuals.
作者信息
Hawkins J R
机构信息
Imperial Cancer Research Fund, London, UK.
出版信息
Horm Res. 1992;38 Suppl 2:62-5. doi: 10.1159/000182599.
PMID:1292984
Abstract
A candidate for the male sex determining gene 2 has recently been isolated. This gene, named SRY, has an expression profile consistent with a role in testis determination, is mutated in some XY females, and causes female to male sex reversal in transgenic mice. The cloning of this gene should facilitate the characterization of other genes in the testis determining pathway.
摘要
最近已分离出一种男性性别决定基因2的候选基因。这个名为SRY的基因，其表达谱与在睾丸决定中所起的作用一致，在一些XY女性中发生突变，并在转基因小鼠中导致雌性向雄性的性反转。该基因的克隆应有助于确定睾丸决定途径中其他基因的特征。
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