采用毛细管电泳法分析抗癫痫药物开浦兰。
Analysis of the antiepileptic drug keppra by capillary electrophoresis.
作者信息
Shihabi Z K, Oles K, Hinsdale M
机构信息
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
出版信息
J Chromatogr A. 2003 Jul 4;1004(1-2):9-12. doi: 10.1016/s0021-9673(03)00716-7.
Abstract
A simple and rapid method for determination of the new antiepileptic drug keppra (levetiracetam) by capillary electrophoresis in borate buffer containing sodium dodecyl sulfate is described. The serum was injected without any treatment. The method compared well to high performance liquid chromatography. The mean of keppra in the serum of 35 patients was 25 mg/l (range 7-77 mg/l).
摘要
描述了一种在含十二烷基硫酸钠的硼酸盐缓冲液中通过毛细管电泳测定新型抗癫痫药物开浦兰（左乙拉西坦）的简单快速方法。血清无需任何处理即可进样。该方法与高效液相色谱法相比效果良好。35例患者血清中开浦兰的平均值为25mg/l（范围7 - 77mg/l）。
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