Hanvivatvong Orrawadee, Tirawatnapong Suranan, Kaowopas Yadah, Jitapankul Sutthichai
Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
J Med Assoc Thai. 2003 Jun;86 Suppl 2:S242-9.
To investigate the prevalence of autoantibodies in a normal Thai elderly group, the authors measured anti-thyroid antibodies (anti-thyroglobulin, anti-thyroid microsome), antinuclear antibodies (ANA) and rheumatoid factors (RF) in 429 normal elderly (206 men, 223 women, age range 50-102 years). The participants recruited from Romklao Village, Lat Krabang, a suburb of Bangkok and compared to 219 young normal subjects (110 men, 109 women; age range 19-49 years). The prevalence of anti-thyroid antibodies was significantly increased in the elderly group when compared to the younger age control group (14.69% vs 5.02%, p = 0.0005). The antibody titers were found to be higher and the prevalence was more predominant in women than in men both in the elderly (21.53% vs 7.28%, p = 0.00005) and control groups (10.09% vs 0%, p = 0.0018). The prevalence of ANA in the elderly group was lower (1.17%) when compared to the control group (4.11%). ANA were characterized by low titer of antibodies and several staining patterns, and there was no difference between men and women. For RF, the prevalence was almost the same in both groups (2.79% in the elderly and 2.73% in control group) and no difference was observed. However, when all the three autoantibodies were considered, 20.28 per cent of the elderly individuals were found to have at least one of the autoantibodies which was significantly higher than in the younger control group (11.41%, p = 0.006). The prevalence was more predominant in women than in men. The results from this study can be used as basic data for the evaluation of autoantibodies testing in an elderly Thai population.
为调查泰国正常老年人群体中自身抗体的流行情况，作者检测了429名正常老年人（206名男性，223名女性，年龄范围50 - 102岁）的抗甲状腺抗体（抗甲状腺球蛋白、抗甲状腺微粒体）、抗核抗体（ANA）和类风湿因子（RF）。参与者招募自曼谷郊区拉差邦的隆考村，并与219名年轻正常受试者（110名男性，109名女性；年龄范围19 - 49岁）进行比较。与年轻对照组相比，老年组抗甲状腺抗体的流行率显著增加（14.69%对5.02%，p = 0.0005）。在老年组和对照组中，均发现女性的抗体滴度更高且流行率比男性更显著（老年组中21.53%对7.28%，p = 0.00005；对照组中10.09%对0%，p = 0.0018）。与对照组（4.11%）相比，老年组ANA的流行率较低（1.17%）。ANA的特点是抗体滴度低且有几种染色模式，男女之间无差异。对于RF，两组的流行率几乎相同（老年组为2.79%，对照组为2.73%），未观察到差异。然而，当考虑所有三种自身抗体时，发现20.28%的老年人至少有一种自身抗体，这显著高于年轻对照组（11.41%，p = 0.006）。女性的流行率比男性更显著。本研究结果可作为评估泰国老年人群体自身抗体检测的基础数据。
