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Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging.循环中初始CD8(+) T细胞的短缺为衰老免疫缺陷提供了新见解。
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Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer.
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CD8β/CD28表达可定义外周血T淋巴细胞的功能不同群体。

CD8beta/CD28 expression defines functionally distinct populations of peripheral blood T lymphocytes.

作者信息

Werwitzke S, Tiede A, Drescher B E, Schmidt R E, Witte T

机构信息

Departments of Clinical Immunology and Haematology and Oncology, Hannover Medical School, Hannover, Germany.

出版信息

Clin Exp Immunol. 2003 Sep;133(3):334-43. doi: 10.1046/j.1365-2249.2003.02226.x.

DOI:10.1046/j.1365-2249.2003.02226.x
PMID:12930358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1808803/
Abstract

Peripheral blood CD8+ T lymphocytes generally express the CD8 coreceptor as an alphabeta heterodimer. On these cells, the CD8beta chain is present either at high (CD8betahigh) or low density (CD8betalow). CD8betahigh cells are CD28+, whereas CD8betalow cells are CD28+ or CD28-. Therefore, three subpopulations of CD8+ T cells can be described: (i) CD8betahighCD28+ (ii) CD8betalowCD28+, and (iii) CD8betalowCD28- cells. Phenotypic and functional characterization of these CD8+ T cell subsets revealed significant differences. CD8betahighCD28+ cells predominantly express CD45RA. In contrast, CD8betalowCD28+ cells frequently express CD45R0 and the activating NK receptor CD161. CD8betalowCD28- cells frequently revert to the CD45RA phenotype. In addition, these cells express CD16, CD56, CD94, and the killer-inhibitory receptors NKB1 and CD158a. Intracellular IL-2 was frequently detected in CD8betahighCD28+ cells and CD8betalowCD28+ cells, but not CD8betalowCD28- cells. CD8betalowCD28+ cells and CD8betalowCD28- cells frequently stained positive for IFN-gamma. In addition, these cells contain intracellular perforin and granzyme A. Expression of Fas (CD95) as well as susceptibility to apoptosis is markedly increased in CD8betalowCD28+ and CD8betalowCD28- cells as compared to CD8betahighCD28+ cells. In vitro activation of peripheral blood lymphocytes triggered expansion of CD8betahighCD28+ cells as well as a development into CD8betalowCD28+ and CD8betalowCD28- cells. Similarly, activation of CD8betahighCD28+ cord blood cells resulted in the appearance of CD8betalowCD28+ and CD8betalowCD28- cells. These data suggest that CD8betahighCD28+ cells can differentiate into CD8betalowCD28+ and CD8betalowCD28- cells upon TCR stimulation. Therefore, the CD8beta/CD28 subsets in peripheral blood may reflect distinct stages of post-thymic CD8+T cell development.

摘要

外周血CD8 + T淋巴细胞通常将CD8共受体表达为αβ异二聚体。在这些细胞上，CD8β链以高密度（CD8β高）或低密度（CD8β低）存在。CD8β高细胞为CD28 +，而CD8β低细胞为CD28 +或CD28 -。因此，可以描述CD8 + T细胞的三个亚群：（i）CD8β高CD28 +（ii）CD8β低CD28 +，和（iii）CD8β低CD28 -细胞。这些CD8 + T细胞亚群的表型和功能特征显示出显著差异。CD8β高CD28 +细胞主要表达CD45RA。相比之下，CD8β低CD28 +细胞经常表达CD45R0和激活的NK受体CD161。CD8β低CD28 -细胞经常恢复为CD45RA表型。此外，这些细胞表达CD16、CD56、CD94以及杀伤抑制受体NKB1和CD158a。在CD8β高CD28 +细胞和CD8β低CD28 +细胞中经常检测到细胞内IL-2，但在CD8β低CD28 -细胞中未检测到。CD8β低CD28 +细胞和CD8β低CD28 -细胞经常被IFN-γ染色呈阳性。此外，这些细胞含有细胞内穿孔素和颗粒酶A。与CD8β高CD28 +细胞相比，CD8β低CD28 +和CD8β低CD28 -细胞中Fas（CD95）的表达以及对细胞凋亡的敏感性明显增加。外周血淋巴细胞的体外激活触发了CD8β高CD28 +细胞的扩增以及向CD8β低CD28 +和CD8β低CD28 -细胞的发育。同样，CD8β高CD28 +脐血细胞的激活导致CD8β低CD28 +和CD8β低CD28 -细胞的出现。这些数据表明，CD8β高CD28 +细胞在TCR刺激后可分化为CD8β低CD28 +和CD8β低CD28 -细胞。因此，外周血中的CD8β/CD28亚群可能反映了胸腺后CD8 + T细胞发育的不同阶段。