临床利弊辩论：脓毒症患者应避免使用羟乙基淀粉。
Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patients.
作者信息
Schortgen Frédérique, Brochard Laurent, Burnham Ellen, Martin Greg S
机构信息
Réanimation Médicale et Infectieuse, Hôpital Bichat-Claude Bernard, Paris, France.
出版信息
Crit Care. 2003 Aug;7(4):279-81. doi: 10.1186/cc1885. Epub 2003 Feb 19.
Abstract
There are few issues in critical care medicine that have a less clearly defined standard of care than the intravenous fluid choice for resuscitation. Natural colloids (such as albumin) became popular during the Second World War when there was a need to develop a portable, easily stored, blood substitute. Early successes led to widespread use and a multibillion dollar industry. It is not surprising given the large demand, high costs and potential adverse effects of natural colloids that synthetic colloids have emerged. In the present article, two groups of clinical investigators remind us of the controversies surrounding the use of synthetic colloids.
摘要
在重症监护医学中，很少有问题的治疗标准比复苏时静脉输液的选择更不明确。天然胶体（如白蛋白）在第二次世界大战期间开始流行，当时需要开发一种便于携带、易于储存的血液替代品。早期的成功导致了其广泛使用，并形成了一个价值数十亿美元的产业。鉴于天然胶体的巨大需求、高昂成本和潜在的不良反应，合成胶体的出现也就不足为奇了。在本文中，两组临床研究人员提醒我们注意围绕合成胶体使用的争议。
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Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group.低蛋白血症可预测脓毒症患者发生急性呼吸窘迫综合征、体重增加及死亡情况。布洛芬治疗脓毒症研究组。
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