Gilliam Frank
Washington University Epilepsy Program, Campus Box 8111, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Curr Neurol Neurosci Rep. 2003 Jul;3(4):357-62. doi: 10.1007/s11910-003-0014-0.
Epilepsy is a chronic disorder that has complex effects on many aspects of personal health. Recent advances in the methods to reliably and validly assess subjective health status have allowed major advances in our understanding of these diverse effects, and have also provided evidence to guide treatment and future research. Studies that have included measures of quality of life, patient preferences, and disability in epilepsy have shown that the magnitude of the adverse effects of recurrent seizures on many aspects of subjective health status is as large as that seen with diabetes mellitus and active cardiovascular disease. Studies of patient-oriented, comprehensive outcomes after epilepsy surgery indicate positive treatment effects in broad areas of function and well-being. Although few trials of epilepsy drugs have included health outcome instruments, available studies suggest that greater than 50% seizure reduction is associated with improved quality of life. Adverse medication effects and depression appear to have a strong association with subjective health status in epilepsy, independent of seizure frequency.
癫痫是一种慢性疾病，对个人健康的许多方面都有复杂影响。在可靠且有效地评估主观健康状况的方法上，近来取得的进展使我们在理解这些多样影响方面取得了重大进步，也为指导治疗及未来研究提供了证据。纳入癫痫患者生活质量、患者偏好及残疾状况测量的研究表明，反复发作的癫痫对主观健康状况诸多方面产生的不利影响程度，与糖尿病和活动性心血管疾病所见的不利影响程度相当。对癫痫手术后以患者为导向的综合结果的研究表明，在广泛的功能和幸福领域均有积极的治疗效果。尽管很少有癫痫药物试验纳入健康结局指标，但现有研究表明，癫痫发作减少超过50%与生活质量改善相关。药物不良反应和抑郁似乎与癫痫患者的主观健康状况密切相关，且与癫痫发作频率无关。
