Dodrill Carl B., Morris George L.
Epilepsy Behav. 2001 Feb;2(1):46-53. doi: 10.1006/ebeh.2000.0148.
To evaluate the cognitive and quality-of-life (QOL) impacts of vagal nerve stimulation (VNS), 160 patients with uncontrolled partial seizures from 20 sites were enrolled in a double-blind study. Patients were randomly assigned to low (minimal) stimulation (n = 82) or high (now clinically used) stimulation (n = 78) conditions and given a group of cognitive and QOL tests before implantation and after 12-16 weeks of VNS treatment. Results showed no clear cognitive changes. However, fewer emotional and physical problems were reported by the High Group than the Low Group at the end of the study. The 32 patients who had at least 50% seizure relief showed slightly more improvement in QOL variables than those patients who did not demonstrate this degree of seizure reduction. Overall, a small number of favorable QOL but no cognitive changes were associated with levels of VNS stimulation that are now typically used clinically.
为评估迷走神经刺激（VNS）对认知和生活质量（QOL）的影响，来自20个地点的160例未得到控制的部分性癫痫患者被纳入一项双盲研究。患者被随机分配至低（最小）刺激组（n = 82）或高（目前临床使用）刺激组（n = 78），并在植入前以及VNS治疗12 - 16周后接受一组认知和生活质量测试。结果显示无明显认知变化。然而，在研究结束时，高刺激组报告的情感和身体问题比低刺激组少。癫痫发作缓解至少50%的32例患者在生活质量变量方面的改善略多于未达到这种癫痫发作减少程度的患者。总体而言，目前临床常用的VNS刺激水平与少量良好的生活质量改善相关，但与认知变化无关。
