Cunha G R, Alarid E T, Turner T, Donjacour A A, Boutin E L, Foster B A
Department of Anatomy, University of California, San Francisco 94143.
J Androl. 1992 Nov-Dec;13(6):465-75.
Androgen-dependent male urogenital development occurs via mesenchymal-epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes expression of tissue-specific secretory proteins. Mesenchymal-epithelial interactions continue to be important into adulthood. For example, mesenchyme of the urogenital sinus (UGM) and seminal vesicle (SVM) induce dramatic morphologic and functional changes in various adult epithelia. Since adult epithelial cells are unquestionably responsive to mesenchymes that can elicit expression of alternative morphologic and functional phenotypes, established carcinomas might also be influenced by their connective tissue environment. In this regard, Dunning prostatic tumor has been induced by UGM or SVM to differentiate into tall columnar secretory epithelial cells. This change in cytodifferentiation is associated with a reduction in growth rate and loss of tumorigenesis. The role of soluble growth factors in the mechanism of mesenchymal-epithelial interactions is discussed.
雄激素依赖的男性泌尿生殖系统发育通过间充质-上皮相互作用发生，其中间充质诱导上皮形态发生、调节上皮增殖并引发组织特异性分泌蛋白的表达。间充质-上皮相互作用在成年期仍然很重要。例如，泌尿生殖窦（UGM）和精囊（SVM）的间充质在各种成年上皮中诱导显著的形态和功能变化。由于成年上皮细胞无疑对能够引发替代形态和功能表型表达的间充质有反应，已建立的癌也可能受到其结缔组织环境的影响。在这方面，邓宁前列腺肿瘤已被UGM或SVM诱导分化为高柱状分泌上皮细胞。这种细胞分化的变化与生长速率降低和肿瘤发生丧失有关。本文讨论了可溶性生长因子在间充质-上皮相互作用机制中的作用。
