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糖尿病足和压疮的伤口愈合方案。

Wound-healing protocols for diabetic foot and pressure ulcers.

作者信息

Brem Harold, Jacobs Tom, Vileikyte Loretta, Weinberger Sarah, Gibber Mark, Gill Kiran, Tarnovskaya Alina, Entero Hyacinth, Boulton Andrew J M

机构信息

Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, NY, USA.

出版信息

Surg Technol Int. 2003;11:85-92.

Abstract

Diabetic foot and pressure ulcers are chronic wounds by definition. They share similar pathogeneses; i.e., a combination of increased pressure and decreased angiogenic response. Neuropathy, trauma, and deformity also often contribute to development of both types of ulcers. Early intervention and proper treatment should result in complete healing of non-ischemic diabetic foot and pressure ulcers, as defined by 100% epithelialization and no drainage (if no osteomyelitis is present). The authors developed the following paradigm, which has proved to be highly effective for complete healing of these wounds: 1) recognition that all patients with limited mobility are at risk for a sacral, ischial, trochanteric, or heel pressure ulcer; 2) daily self-examination of the sacral, ischium, buttocks, hips, and heels of all bed-bound patients and the feet of patients with diabetes with risk factors (e.g., neuropathy); 3) initiation of a treatment protocol immediately upon recognition of a break in the skin (i.e., emergence of a new wound); 4) objective measurement by planimetry of every wound (at a minimum, weekly) and documentation of its progress; 5) establishment of a moist wound-healing environment; 6) relief of pressure from the wound; 7) debridement of all non-viable tissue in the wound; 8) elimination of all drainage and cellulitis; 9) cellular therapy or growth factors for patients with wounds that do not heal rapidly after initial treatment; and 10) continuous physical and psychosocial support for all patients. If this paradigm is followed, most diabetic foot and pressure ulcers are expected to heal.

摘要

根据定义,糖尿病足和压疮均为慢性伤口。它们具有相似的发病机制,即压力增加与血管生成反应降低相结合。神经病变、创伤和畸形也常常促使这两种溃疡的形成。如定义为100%上皮化且无引流(若不存在骨髓炎),早期干预和恰当治疗应能使非缺血性糖尿病足和压疮完全愈合。作者制定了以下模式,事实证明该模式对于这些伤口的完全愈合非常有效:1)认识到所有行动不便的患者都有发生骶部、坐骨、大转子或足跟压疮的风险;2)对所有卧床患者的骶部、坐骨、臀部、髋部和足跟以及有危险因素(如神经病变)的糖尿病患者的足部进行每日自我检查;3)一旦发现皮肤破损(即出现新伤口),立即启动治疗方案;4)通过平面测量法对每个伤口进行客观测量(至少每周一次)并记录其进展情况;5)营造湿润的伤口愈合环境;6)减轻伤口压力;7)清除伤口内所有无活力组织;8)消除所有引流和蜂窝织炎;9)对于初始治疗后伤口愈合缓慢的患者,采用细胞治疗或生长因子;10)为所有患者提供持续的身体和心理社会支持。如果遵循这一模式,大多数糖尿病足和压疮有望愈合。

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