Department of Neuropeptides, Mossakowski Medical Research Institute Polish Academy of Sciences, 5 Pawińskiego Street, PL 02-106 Warsaw, Poland.
Int J Mol Sci. 2022 Jan 11;23(2):750. doi: 10.3390/ijms23020750.
Wound healing is a highly coordinated process which leads to the repair and regeneration of damaged tissue. Still, numerous diseases such as diabetes, venous insufficiencies or autoimmune diseases could disturb proper wound healing and lead to chronic and non-healing wounds, which are still a great challenge for medicine. For many years, research has been carried out on finding new therapeutics which improve the healing of chronic wounds. One of the most extensively studied active substances that has been widely tested in the treatment of different types of wounds was Substance P (SP). SP is one of the main neuropeptides released by nervous fibers in responses to injury. This review provides a thorough overview of the application of SP in different types of wound models and assesses its efficacy in wound healing.
伤口愈合是一个高度协调的过程，导致受损组织的修复和再生。尽管如此，许多疾病，如糖尿病、静脉功能不全或自身免疫性疾病，可能会干扰适当的伤口愈合，并导致慢性和非愈合性伤口，这仍然是医学的一大挑战。多年来，人们一直在研究寻找新的治疗方法，以改善慢性伤口的愈合。其中一种研究最广泛的活性物质是 P 物质 (SP)，它已被广泛测试用于治疗不同类型的伤口。本文综述了 SP 在不同类型伤口模型中的应用，并评估了其在伤口愈合中的疗效。
