Noblett Kurtis L, Swain Rodney A
Department of Psychology, University of Wisconsin-Milwaukee, 53201, USA.
Behav Neurosci. 2003 Aug;117(4):785-98. doi: 10.1037/0735-7044.117.4.785.
Following bilateral lesions targeting lateral deep cerebellar nuclei, rats were subjected to a bridge test as a measure of visuomotor coordination and were trained on the Morris water maze (MWM) as a measure of visuospatial processing. Lesioned rats were significantly impaired in visuospatial processing, but not visuomotor coordination, relative to sham rats. In a 2nd experiment, rats were pretrained on a delayed spatial alternation task (T maze) before MWM training. Pretraining reversed the visuospatial deficit caused by the lesions as compared with nonpretrained rats. Results suggest that lateral deep cerebellar nuclei contribute to visuospatial processing with a negligible contribution to visuomotor skills and that visuospatial deficits resulting from lateral nuclei damage can be reversed with pretraining on aspatial working memory task.
在双侧损伤外侧小脑深部核团后，对大鼠进行桥测试以评估视觉运动协调性，并在莫里斯水迷宫（MWM）中进行训练以评估视觉空间处理能力。与假手术大鼠相比，损伤大鼠在视觉空间处理方面明显受损，但在视觉运动协调性方面未受损。在第二个实验中，大鼠在MWM训练前先在延迟空间交替任务（T迷宫）上进行预训练。与未预训练的大鼠相比，预训练逆转了损伤所致的视觉空间缺陷。结果表明，外侧小脑深部核团对视觉空间处理有贡献，对视觉运动技能的贡献可忽略不计，并且外侧核团损伤导致的视觉空间缺陷可通过在空间工作记忆任务上的预训练得到逆转。
