Joyal C C, Strazielle C, Lalonde R
Département de psychologie, Université de Montréal, Montreal, Que., Canada H3C 3J7.
Behav Brain Res. 2001 Aug 1;122(2):131-7. doi: 10.1016/s0166-4328(00)00390-9.
The role of the dentate nucleus on spatial orientation, assessed by the Morris water maze test, and on postural sensorimotor performance, assessed by vertical grid, suspended wire, and rotorod tests, was investigated. Bilateral electrolytic lesions of the dentate nucleus slowed down the acquisition of the hidden platform task of the Morris water maze, without affecting long-term retention, the probe trial, and the visuomotor guidance necessary for swimming toward a visible goal. In addition, reversal learning was impaired in the submerged platform condition. The lesions did not affect any of the motor performance scores. The selective impairment seen during acquisition of the hidden platform task is similar to that previously reported in rats with combined lesions of the cerebellar hemispheres and dentate, indicating a specific role for this region in spatial orientation.
通过莫里斯水迷宫试验评估齿状核在空间定向中的作用，以及通过垂直网格、悬线和转棒试验评估其在姿势感觉运动性能中的作用。对齿状核进行双侧电解损伤会减慢莫里斯水迷宫隐藏平台任务的获得速度，但不影响长期记忆、探索试验以及向可见目标游泳所需的视觉运动引导。此外，在水下平台条件下，逆向学习受损。损伤不影响任何运动性能评分。在隐藏平台任务获得过程中观察到的选择性损伤与先前报道的小脑半球和齿状核联合损伤的大鼠相似，表明该区域在空间定向中具有特定作用。
