首次酶促合成具有次黄嘌呤部分结构的N1-环化cADPR（环磷酸腺苷核糖）类似物：发现一种可透过膜的cADPR激动剂。
First enzymatic synthesis of an N1-cyclised cADPR (cyclic-ADP ribose) analogue with a hypoxanthine partial structure: discovery of a membrane permeant cADPR agonist.
作者信息
Wagner Gerd K, Black Steven, Guse Andreas H, Potter Barry V L
机构信息
University of Bath, Department of Pharmacy and Pharmacology, Wolfson Laboratory of Medicinal Chemistry, Claverton Down, Bath, UK BA2 7AY.
出版信息
Chem Commun (Camb). 2003 Aug 7(15):1944-5. doi: 10.1039/b305660k.
DOI:10.1039/b305660k
PMID:12932045
Abstract
Nicotinamide 8-Br-hypoxanthine dinucleotide (8-Br-NHD+) was cyclised at the N1 position by the ADP-ribosyl cyclase from Aplysia californica to give cyclic 8-Br-inosine diphosphoribose (8-Br-N1-cIDPR), a novel membrane-permeant agonist of Ca2+ release in human T cells.
摘要
烟酰胺8-溴次黄嘌呤二核苷酸（8-Br-NHD+）在来自加州海兔的ADP-核糖基环化酶作用下于N1位环化，生成环状8-溴肌苷二磷酸核糖（8-Br-N1-cIDPR），一种新型的可透过细胞膜的人T细胞中Ca2+释放激动剂。
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