The Calcium Signalling Group, Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.
Molecules. 2020 Sep 15;25(18):4220. doi: 10.3390/molecules25184220.
Ca-mobilizing adenine nucleotide second messengers cyclic adenosine diphosphoribose, (cADPR), nicotinic acid adenine dinucleotide phosphate (NAADP), adenosine diphosphoribose (ADPR), and 2'deoxy-ADPR were discovered since the late 1980s. They either release Ca from endogenous Ca stores, e.g., endoplasmic reticulum or acidic organelles, or evoke Ca entry by directly activating a Ca channel in the plasma membrane. For 25 years, Professor Barry Potter has been one of the major medicinal chemists in this topical area, designing and contributing numerous analogues to develop structure-activity relationships (SAR) as a basis for tool development in biochemistry and cell biology and for lead development in proof-of-concept studies in disease models. With this review, I wish to acknowledge our 25-year-long collaboration on Ca-mobilizing adenine nucleotide second messengers as a major part of Professor Potter's scientific lifetime achievements on the occasion of his retirement in 2020.
自 20 世纪 80 年代末以来，钙动员腺嘌呤核苷酸第二信使环腺苷二磷酸核糖（cADPR）、烟酸腺嘌呤二核苷酸磷酸（NAADP）、二磷酸腺苷核糖（ADPR）和 2'-脱氧-ADPR 被发现。它们或者从内源性钙库（如内质网或酸性细胞器）释放 Ca，或者通过直接激活质膜中的 Ca 通道来引发 Ca 内流。25 年来，Barry Potter 教授一直是该领域的主要药物化学家之一，他设计并提供了许多类似物，以建立结构-活性关系（SAR），作为生物化学和细胞生物学工具开发以及疾病模型中概念验证研究先导化合物开发的基础。在 2020 年退休之际，我希望通过这篇综述，承认我们在钙动员腺嘌呤核苷酸第二信使方面长达 25 年的合作，这是 Potter 教授毕生科学成就的重要组成部分。
