Stierle Andrea A, Stierle Donald B, Goldstein Eric, Parker Keith, Bugni Tim, Baarson Chad, Gress Julie, Blake Danielle
Department of Chemistry, Montana Tech of The University of Montana, Butte, Montana 59701, USA.
J Nat Prod. 2003 Aug;66(8):1097-100. doi: 10.1021/np030044w.
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
位于蒙大拿州比尤特的伯克利矿坑湖是一个富含有毒金属的酸性矿山废水蓄水池。从该矿坑湖分离出的一种皮托霉属真菌产生了三种酪氨酸衍生物（1 - 3），其中一种作为5 - HT（(2a)）受体配体。这种活性类型与偏头痛预防药物和抗高血压药物有关。本文报道了化合物1 - 3以及先前从高等植物中分离出的三种倍半萜（5 - 7）的分离和表征。
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