伯克利缩醛，来自酸性矿井废水青霉的三种半萜。
The berkeleyacetals, three meroterpenes from a deep water acid mine waste Penicillium.
作者信息
Stierle Donald B, Stierle Andrea A, Patacini Brianna
机构信息
Department of Chemistry, Montana Tech of University of Montana, Butte, Montana 59701, USA.
出版信息
J Nat Prod. 2007 Nov;70(11):1820-3. doi: 10.1021/np070329z. Epub 2007 Oct 31.
Abstract
Berkeley Pit Lake is a 1500 ft deep abandoned open-pit copper mine filled with over 1140 billion liters of acidic, metal-sulfate-contaminated water. This harsh environment is proving to be a source of unusual microorganisms that produce novel bioactive compounds. We recently reported the structures of berkeleydione (1) and berkeleytrione (2), two novel hybrid polyketide-terpenoid metabolites isolated from a deep water Penicillium sp. growing in Berkeley Pit Lake. In this paper we report the structures of three new compounds, berkeleyacetals A-C ( 3-5) isolated from extracts of this fungus. The structures of these compounds were deduced by comparison of mass spectral and NMR data to that of berkeleydione (1).
摘要
伯克利矿坑湖是一个深达1500英尺的废弃露天铜矿，其中充满了超过11400亿升受酸性金属硫酸盐污染的水。事实证明，这种恶劣环境是产生新型生物活性化合物的异常微生物的来源。我们最近报道了伯克利二酮（1）和伯克利三酮（2）的结构，这两种新型的聚酮-萜类杂合代谢产物是从生长在伯克利矿坑湖深水中的青霉菌中分离得到的。在本文中，我们报道了从该真菌提取物中分离得到的三种新化合物，伯克利缩醛A-C（3-5）的结构。通过将质谱和核磁共振数据与伯克利二酮（1）的数据进行比较，推断出了这些化合物的结构。
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