来源于海绵内生真菌 Stachylidium sp. 的 Stachylines A-D
Stachylines A-D from the sponge-derived fungus Stachylidium sp.
机构信息
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
出版信息
J Nat Prod. 2011 Jan 28;74(1):21-5. doi: 10.1021/np1005345. Epub 2010 Dec 16.
Abstract
The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.
摘要
海洋来源的真菌 Stachylidium sp. 从海绵 Callyspongia cf. C. flammea 中分离得到。从真菌提取物中获得了四个新的、假定的酪氨酸衍生的和 O-异戊烯基化的天然产物，分别为 stachylines A-D（1-4）。基于广泛的光谱分析确定了 1-4 的结构。通过 Mosher 法确定了化合物 2 的绝对构型。stachyline A（1）具有罕见的末端肟基团，并且以 E/Z-异构体的可互换混合物形式存在。
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