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使用血管内超声进行移植物规划和部署的腔内腹主动脉瘤修复:基于社区的2年经验。

Endoluminal AAA repair using intravascular ultrasound for graft planning and deployment: a 2-year community-based experience.

作者信息

Slovut David P, Ofstein Lewis C, Bacharach J Michael

机构信息

Department of Cardiology, Mount Sinai Medical Center, New York, New York, USA.

出版信息

J Endovasc Ther. 2003 Jun;10(3):463-75. doi: 10.1177/152660280301000311.

Abstract

PURPOSE

To examine the effectiveness of intravascular ultrasound (IVUS) and digital subtraction angiography (DSA) for preoperative planning and intraoperative deployment of stent-grafts to treat abdominal aortic aneurysms.

METHODS

One hundred seventy patients (143 men; mean age 73.6+/-7.2 years, range 51-89) underwent successful DSA and IVUS to determine suitability for stent-graft repair. Patients subsequently received the AneuRx (n=157) or Ancure (n=13) device; intraprocedural IVUS was used to survey the proximal endograft for proper apposition to the aortic wall.

RESULTS

Reliable preoperative IVUS measurements were obtained in all patients. Plaque morphology was assessed in 140 (82.3%) aortic necks; in 36 (25.7%), preoperative IVUS showed high-grade atherosclerotic plaque in the nonaneurysmal abdominal aortic neck. The procedure was successful in 168 (98.8%) cases (1 [0.6%] acute conversion and 1 access failure). There were 2 (1.2%) periprocedural deaths related to bowel ischemia. Four (2.3%) patients developed graft occlusion/kinking and 2 (1.2%) developed renal failure requiring dialysis within 30 days. Multivariate logistic regression analysis revealed that female gender (p=0.0247), a short nonaneurysmal aortic neck (p=0.0185), and presence of high-grade atherosclerotic plaque (p=0.0185) correlated with major acute complications. Over a mean 10.4-month follow-up (range 1-25), 11 patients died of unrelated causes; there was no known AAA rupture or device failure. The Kaplan-Meier estimate of survival at 1 year was 91.0%+/-2.8%. Sixteen (9.4%) patients underwent 17 secondary procedures for endoleak or graft limb occlusion at a mean 5.4 months after stent-graft repair (freedom from secondary intervention at 1 year 86.5%+/-3.2%).

CONCLUSIONS

Our findings suggest that IVUS may identify patients at increased risk of major adverse complications following endovascular repair. The combination of IVUS and DSA for endoluminal stent-graft planning and placement provides excellent short- and mid-term patient outcomes.

摘要

目的

研究血管内超声(IVUS)和数字减影血管造影(DSA)在腹主动脉瘤支架移植物术前规划及术中植入中的有效性。

方法

170例患者(143例男性;平均年龄73.6±7.2岁,范围51 - 89岁)成功接受了DSA和IVUS检查以确定是否适合进行支架移植物修复。患者随后接受了AneuRx(n = 157)或Ancure(n = 13)装置;术中使用IVUS检查近端移植物与主动脉壁的贴合情况。

结果

所有患者均获得了可靠的术前IVUS测量结果。对140例(82.3%)主动脉颈部进行了斑块形态评估;其中36例(25.7%)术前IVUS显示非动脉瘤性腹主动脉颈部存在高度动脉粥样硬化斑块。手术成功168例(98.8%)(1例[0.6%]急性中转开腹,1例穿刺失败)。围手术期有2例(1.2%)死亡,与肠缺血有关。4例(2.3%)患者出现移植物闭塞/扭结,2例(1.2%)患者在30天内出现需要透析的肾衰竭。多因素逻辑回归分析显示,女性(p = 0.0247)、非动脉瘤性主动脉颈部较短(p = 0.0185)以及存在高度动脉粥样硬化斑块(p = 0.0185)与主要急性并发症相关。平均随访10.4个月(范围1 - 25个月),11例患者死于无关原因;未发现已知的腹主动脉瘤破裂或装置故障。1年时的Kaplan - Meier生存估计值为91.0%±2.8%。16例(9.4%)患者在支架移植物修复后平均5.4个月因内漏或移植物肢体闭塞接受了17次二次手术(1年时无需二次干预的概率为86.5%±3.2%)。

结论

我们的研究结果表明,IVUS可能识别出血管内修复后发生主要不良并发症风险增加的患者。IVUS和DSA联合用于腔内支架移植物的规划和放置可提供良好的短期和中期患者预后。

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