Schneider I H, Grabenbauer G G, Reck T, Köckerling F, Sauer R, Gall F P
Department of Surgery, University Hospital of Erlangen, Federal Republic of Germany.
Int J Colorectal Dis. 1992 Dec;7(4):192-6. doi: 10.1007/BF00341219.
Between 1985 and 1992, 46 patients with epidermoid carcinoma of the anal canal were treated prospectively by a protocol of combined radiation and chemotherapy with 5-Fluorouracil and Mitomycin C. The survival rate, NED-survival rate and local tumour control rate were 84%, 71% and 83% at 5 years. Anorectal function was retained in 33 of 41 patients (80%). We observed severe acute toxicity including three deaths, but very little late morbidity. The only marginally significant prognostic factor (P = 0.06) for local tumour control was T-stage. NED-survival was significantly affected (P = 0.02) by reduction of chemotherapy during the second course.
1985年至1992年间，对46例肛管表皮样癌患者采用5-氟尿嘧啶和丝裂霉素C联合放疗及化疗方案进行前瞻性治疗。5年时的生存率、无疾病生存（NED）率和局部肿瘤控制率分别为84%、71%和83%。41例患者中有33例（80%）保留了肛肠功能。我们观察到严重的急性毒性反应，包括3例死亡，但晚期发病率很低。局部肿瘤控制的唯一边缘性显著预后因素（P = 0.06）是T分期。第二疗程化疗减量对无疾病生存有显著影响（P = 0.02）。
