[法呢醇醋酸泼尼松龙（PNF）凝胶对皮肤和眼黏膜的影响]
[Effects of prednisolone farnesylate (PNF) gel on skin and ocular mucosa].
作者信息
Uchiyama H, Tanaka T, Uehara N, Nakamura M, Tsuji M, Shinomiya M, Tanaka H
机构信息
Kyudo Laboratory of Safety Assessment, Kyudo Co., Ltd., Saga, Japan.
出版信息
J Toxicol Sci. 1992 Nov;17 Suppl 3:283-312. doi: 10.2131/jts.17.supplementiii_283.
Various tests for irritation, phototoxicity, contact sensitivity and photocontact sensitivity of PNF gel were conducted. The results were as follows. 1) In the primary dermal irritation test and trypan blue test, slight erythema was noted in the rabbits treated with 0.8 and 1.6% PNF gel, although similar reaction occurred in those treated with the base. 2) In the test for the primary irritation to the ocular mucosa, severe irritant reactions were caused by 0.8 and 1.6% PNF gel and its base. However these reactions disappeared 7 days after irritation. 3) In the phototoxicity test and contact sensitivity test, no positive reactions were detected by 0.8 and 1.6% PNF gel. On the other hand, in the photocontact sensitivity test, positive reaction were noted in the guinea pig treated with 0.8 and 1.6% PNF gel and its base.
对PNF凝胶进行了多种刺激、光毒性、接触敏感性和光接触敏感性测试。结果如下：1）在原发性皮肤刺激试验和台盼蓝试验中，用0.8%和1.6%PNF凝胶处理的兔子出现轻微红斑，不过用基质处理的兔子也出现了类似反应。2）在眼黏膜原发性刺激试验中，0.8%和1.6%PNF凝胶及其基质引起了严重的刺激反应。然而，这些反应在刺激7天后消失。3）在光毒性试验和接触敏感性试验中，0.8%和1.6%PNF凝胶未检测到阳性反应。另一方面，在光接触敏感性试验中，用0.8%和1.6%PNF凝胶及其基质处理的豚鼠出现了阳性反应。
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