化脓性链球菌在多形核细胞内的存活会导致细菌毒力增强。
Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence.
作者信息
Medina Eva, Rohde Manfred, Chhatwal Gursharan S
机构信息
Department of Microbial Pathogenesis and Vaccine Research, GBF-German Research Centre for Biotechnology, Braunschweig, Germany.
出版信息
Infect Immun. 2003 Sep;71(9):5376-80. doi: 10.1128/IAI.71.9.5376-5380.2003.
Abstract
It has recently been shown that survival within phagocytic cells constitutes an additional strategy used by Streptococcus pyogenes to evade the host defenses. Here we provide evidence that S. pyogenes can escape from the phagosome into the cytoplasm of phagocytic cells. Furthermore, intracellular bacteria seem to undergo phenotypic switching that results in much more virulent microorganisms.
摘要
最近的研究表明，化脓性链球菌利用吞噬细胞内的存活作为逃避宿主防御的另一种策略。在此，我们提供证据表明化脓性链球菌能够从吞噬体逃逸到吞噬细胞的细胞质中。此外，细胞内细菌似乎会发生表型转换，从而产生毒性更强的微生物。
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