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Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.产气荚膜梭菌毒力因子是非冗余激活 NLRP3 炎症小体的激活物。
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6
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细菌胆固醇依赖性细胞溶素及其与人体免疫反应的相互作用。

Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.

机构信息

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

出版信息

Curr Opin Infect Dis. 2024 Jun 1;37(3):164-169. doi: 10.1097/QCO.0000000000001010. Epub 2024 Mar 21.

DOI:10.1097/QCO.0000000000001010
PMID:38527455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11042984/
Abstract

PURPOSE OF REVIEW

Many cholesterol-dependent cytolysin (CDC)-producing pathogens pose a significant threat to human health. Herein, we review the pore-dependent and -independent properties CDCs possess to assist pathogens in evading the host immune response.

RECENT FINDINGS

Within the last 5 years, exciting new research suggests CDCs can act to inhibit important immune functions, disrupt critical cell signaling pathways, and have tissue-specific effects. Additionally, recent studies have identified a key region of CDCs that generates robust immunity, providing resources for the development of CDC-based vaccines.

SUMMARY

This review provides new information on how CDCs alter host immune responses to aid bacteria in pathogenesis. These studies can assist in the design of more efficient vaccines and therapeutics against CDCs that will enhance the immune response to CDC-producing pathogens while mitigating the dampening effects CDCs have on the host immune response.

摘要

目的综述

许多依赖胆固醇的细胞溶素（CDC）产生的病原体对人类健康构成重大威胁。在此，我们综述了 CDC 具有的依赖孔和不依赖孔的特性，以帮助病原体逃避宿主免疫反应。

最近的发现

在过去的 5 年中，令人兴奋的新研究表明，CDC 可以抑制重要的免疫功能，破坏关键的细胞信号通路，并具有组织特异性效应。此外，最近的研究确定了 CDC 产生强大免疫的关键区域，为基于 CDC 的疫苗的开发提供了资源。

总结

本综述提供了有关 CDC 如何改变宿主免疫反应以帮助细菌发病机制的新信息。这些研究可以帮助设计更有效的针对 CDC 的疫苗和治疗方法，增强对产生 CDC 的病原体的免疫反应，同时减轻 CDC 对宿主免疫反应的抑制作用。