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用弓形虫表达基因组文库进行疫苗接种引发的长期保护性免疫反应。

Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.

作者信息

Fachado Alberto, Rodriguez Alexandro, Molina Judith, Silvério Jaline C, Marino Ana P M P, Pinto Luzia M O, Angel Sergio O, Infante Juan F, Traub-Cseko Yara, Amendoeira Regina R, Lannes-Vieira Joseli

机构信息

Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.

出版信息

Infect Immun. 2003 Sep;71(9):5407-11. doi: 10.1128/IAI.71.9.5407-5411.2003.

DOI:10.1128/IAI.71.9.5407-5411.2003
PMID:12933894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187360/
Abstract

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.

摘要

用弓形虫表达基因组文库免疫BALB/c小鼠可诱导Th1型免疫反应，识别几种弓形虫蛋白（21至117 kDa），并对致死性攻击产生长期保护性免疫。这些结果支持进一步研究以开发多组分抗弓形虫DNA疫苗。

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Infect Immun. 2003 Sep;71(9):5407-11. doi: 10.1128/IAI.71.9.5407-5411.2003.
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Front Cell Infect Microbiol. 2017 Feb 7;7:34. doi: 10.3389/fcimb.2017.00034. eCollection 2017.
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A comparative study between excretory/secretory and autoclaved vaccines against RH strain of Toxoplasma gondii in murine models.在鼠模型中针对刚地弓形虫RH株的排泄/分泌疫苗与高压灭菌疫苗的对比研究。
J Parasit Dis. 2015 Sep;39(3):526-35. doi: 10.1007/s12639-013-0390-6. Epub 2013 Nov 20.
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Infect Immun. 2005 Nov;73(11):7089-98. doi: 10.1128/IAI.73.11.7089-7098.2005.

本文引用的文献

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Toxoplasmosis: the first commercial vaccine.弓形虫病：首款商业疫苗。
Parasitol Today. 1993 Sep;9(9):335-7. doi: 10.1016/0169-4758(93)90236-9.
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Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice.一种裸DNA疫苗混合物对小鼠致死性弓形虫病的保护作用。
Vaccine. 2003 Mar 28;21(13-14):1327-35. doi: 10.1016/s0264-410x(02)00692-8.
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De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii.从头嘧啶生物合成是刚地弓形虫毒力所必需的。
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4
CD8(+)-T-cell immunity against Toxoplasma gondii can be induced but not maintained in mice lacking conventional CD4(+) T cells.在缺乏传统CD4(+) T细胞的小鼠中，可以诱导出针对刚地弓形虫的CD8(+) T细胞免疫，但无法维持这种免疫。
Infect Immun. 2002 Feb;70(2):434-43. doi: 10.1128/IAI.70.2.434-443.2002.
5
Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules.克氏锥虫引发的心肌炎中 CD8(+)αβ T 细胞的患病率与 CD62L(低)LFA-1(高)VLA-4(高)激活表型的获得以及 IFN-γ 诱导的黏附分子和趋化因子分子的表达相关。
Microbes Infect. 2001 Oct;3(12):971-84. doi: 10.1016/s1286-4579(01)01461-7.
6
Improved vectors for expression library immunization--application to Mycoplasma hyopneumoniae infection in pigs.用于表达文库免疫的改良载体——在猪支原体肺炎感染中的应用
Vaccine. 2001 Oct 12;20(1-2):115-20. doi: 10.1016/s0264-410x(01)00314-0.
7
Genetic immunization with plasmid DNA coding for the ROP2 protein of Toxoplasma gondii.用编码刚地弓形虫ROP2蛋白的质粒DNA进行基因免疫。
Parasitol Res. 2001 Jan;87(1):70-9. doi: 10.1007/s004360000296.
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Toxoplasma gondii: from animals to humans.弓形虫：从动物到人类
Int J Parasitol. 2000 Nov;30(12-13):1217-58. doi: 10.1016/s0020-7519(00)00124-7.
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Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library.通过用cDNA表达文库的连续组分进行免疫来鉴定实验性内脏利什曼病的疫苗候选物。
Infect Immun. 2000 Oct;68(10):5595-602. doi: 10.1128/IAI.68.10.5595-5602.2000.
10
Expression library immunization protects mice against a challenge with virulent rodent malaria.表达文库免疫可保护小鼠免受强毒力啮齿类疟原虫的攻击。
Vaccine. 2000 May 22;18(23):2533-40. doi: 10.1016/s0264-410x(00)00018-9.