用弓形虫表达基因组文库进行疫苗接种引发的长期保护性免疫反应。
Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.
作者信息
Fachado Alberto, Rodriguez Alexandro, Molina Judith, Silvério Jaline C, Marino Ana P M P, Pinto Luzia M O, Angel Sergio O, Infante Juan F, Traub-Cseko Yara, Amendoeira Regina R, Lannes-Vieira Joseli
机构信息
Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
出版信息
Infect Immun. 2003 Sep;71(9):5407-11. doi: 10.1128/IAI.71.9.5407-5411.2003.
Abstract
Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.
摘要
用弓形虫表达基因组文库免疫BALB/c小鼠可诱导Th1型免疫反应，识别几种弓形虫蛋白（21至117 kDa），并对致死性攻击产生长期保护性免疫。这些结果支持进一步研究以开发多组分抗弓形虫DNA疫苗。
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