微小隐孢子虫从MDCK细胞逸出时宿主细胞的命运
Host cell fate on Cryptosporidium parvum egress from MDCK cells.
作者信息
Elliott David A, Clark Douglas P
机构信息
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
出版信息
Infect Immun. 2003 Sep;71(9):5422-6. doi: 10.1128/IAI.71.9.5422-5426.2003.
Abstract
Cryptosporidium parvum is an intracellular protozoan parasite that causes a severe diarrheal illness of unclear etiology. Also unclear is the fate of the host cell upon parasite egress. We show in an MDCK cell model that the host cell is killed upon parasite egress; this death is necrotic, rather than apoptotic, in nature.
摘要
微小隐孢子虫是一种细胞内原生动物寄生虫，可引发病因不明的严重腹泻疾病。寄生虫逸出后宿主细胞的命运也尚不明确。我们在MDCK细胞模型中发现，寄生虫逸出时宿主细胞会死亡；这种死亡本质上是坏死性的，而非凋亡性的。
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