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微小隐孢子虫从MDCK细胞逸出时宿主细胞的命运

Host cell fate on Cryptosporidium parvum egress from MDCK cells.

作者信息

Elliott David A, Clark Douglas P

机构信息

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

出版信息

Infect Immun. 2003 Sep;71(9):5422-6. doi: 10.1128/IAI.71.9.5422-5426.2003.

DOI:10.1128/IAI.71.9.5422-5426.2003
PMID:12933897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187295/
Abstract

Cryptosporidium parvum is an intracellular protozoan parasite that causes a severe diarrheal illness of unclear etiology. Also unclear is the fate of the host cell upon parasite egress. We show in an MDCK cell model that the host cell is killed upon parasite egress; this death is necrotic, rather than apoptotic, in nature.

摘要

微小隐孢子虫是一种细胞内原生动物寄生虫，可引发病因不明的严重腹泻疾病。寄生虫逸出后宿主细胞的命运也尚不明确。我们在MDCK细胞模型中发现，寄生虫逸出时宿主细胞会死亡；这种死亡本质上是坏死性的，而非凋亡性的。

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本文引用的文献

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Ultraviolet B irradiation induces apoptosis of keratinocytes by direct activation of Fas antigen.紫外线B照射通过直接激活Fas抗原诱导角质形成细胞凋亡。
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Cryptosporidium parvum infection requires host cell actin polymerization.微小隐孢子虫感染需要宿主细胞肌动蛋白聚合。
Infect Immun. 2001 Sep;69(9):5940-2. doi: 10.1128/IAI.69.9.5940-5942.2001.
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What is apoptosis, and why is it important?什么是细胞凋亡，它为何重要？
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Cryptosporidium parvum activates nuclear factor kappaB in biliary epithelia preventing epithelial cell apoptosis.微小隐孢子虫激活胆管上皮细胞中的核因子κB，从而防止上皮细胞凋亡。
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Infect Immun. 2000 Apr;68(4):2315-22. doi: 10.1128/IAI.68.4.2315-2322.2000.