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[暴露于煤尘和岩尘的大鼠以及运动过程中肾上腺的细胞形态学和代谢变化]

[Cytomorphological and metabolic changes in the adrenal glands of rats exposed to coal and rock dust and during exercise].

作者信息

Bazeliuk L T

出版信息

Gig Sanit. 2003 Jul-Aug(4):55-7.

PMID:12934291
Abstract

Cytomorphological and cytochemical studies were used to examine 28 experimental non-inbred male rats that had been intratracheally exposed to 50 mg of coal rock dust (CRD) and had concurrently exercises (running) for 2 hours 5 times a week during a 3-month experiment. Toxic and physical factors were found to adversely affect the functional status of the sympathoadrenal systems of adrenal cortical cells (ACC). The most significant impairments of cytomorphological and metabolic changes were observed in ACC under the combined effects of CRD and during exercise.

摘要

采用细胞形态学和细胞化学研究方法,对28只实验性非近交雄性大鼠进行了检测。这些大鼠经气管内暴露于50毫克煤岩粉尘(CRD),并在为期3个月的实验期间,每周5次同时进行2小时的运动(跑步)。发现毒性和物理因素对肾上腺皮质细胞(ACC)的交感肾上腺系统的功能状态产生了不利影响。在CRD和运动的联合作用下,ACC中观察到了最显著的细胞形态学和代谢变化损伤。

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